cHMA is a novel methodology to directly compare morphometric quantities across morphologically and interspecifically variable bones such as trabecular bone. The goal of cHMA is to create a representative canonically averaged shape of all individuals in a sample to serve as a reference to directly compare morphometric quantities between variable bone shapes. This method is a novel extension of Holistic Morphometric Analysis (HMA) which is designed to qualitatively analyze morphometric quantities of whole bone structures without the need of landmark-based approaches or subregions of interest (Bachmann et al., 2022; Gross, Kivell, Skinner, Nguyen, & Pahr, 2014; Steiner et al., 2021). While there have been various HMA approaches (Bachmann et al., 2022), the general workflow has been to standardize each trabecular image domain, create a volumetric mesh of the trabecular bone, calculate the morphometric quantities from the bone image, and interpolate these morphometric values on the generated mesh. Morphometric values are sampled onto the mesh by creating the same 3D background grid for each trabecular bone image in a sample. By using overlapping sampling spheres, the morphometric values of the trabecular bone are assigned to the 3D background grid and then interpolated onto the overlapping mesh.